A plane used as an air ambulance by the Philippine health department to fight the coronavirus outbreak burst into flames as it took off from Manila’s airport for Japan on Sunday night, killing all onboard, the airport said.

The airplane was carrying eight people, including the pilot and two crew members, a doctor, a nurse, a flight medic and an American and a Canadian passenger, according to local radio reports, citing airport officials.

It was not clear whether the passengers were being airlifted for treatment of the viral disease.

“Unfortunately, no passenger survived the accident,” the Manila International Airport Authority said in a statement, adding that the runway had been closed and an investigation was underway.

The Research Institute for Tropical Medicine, the Philippine agency at the forefront of combating the disease, uses the same aircraft from a Philippine charter flight company called Lionair to transport supplies to the medical workers on the front line in the provinces across the archipelago, the government said.